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  • Title: Prothrombin complex concentrate (Beriplex P/N).
    Author: Scott LJ.
    Journal: Drugs; 2009 Oct 01; 69(14):1977-84. PubMed ID: 19747012.
    Abstract:
    Beriplex P/N, a prothrombin complex concentrate derived from pooled human plasma, contains the vitamin K-dependent coagulation factors II, VII, IX and X, and the vitamin K-dependent coagulation inhibition proteins C and S. Intravenous Beriplex P/N provided rapid and sustained normalization of elevated international normalized ratios and controlled bleeding in adult patients participating in several prospective, noncomparative clinical studies (n = 8-43), with these data supported by clinical experience during its use over more than a decade. Based on extensive clinical experience, Beriplex P/N is also effective in the treatment of congenital deficiency of any of the vitamin K-dependent coagulation factors when purified specific coagulation factor products are not available. Over a decade of clinical experience and more limited data from clinical studies have shown that intravenous infusions of Beriplex P/N were generally well tolerated in adult patients with acquired or congenital deficiencies of the vitamin K-dependent coagulation factors. To date, there have been no proven cases of viral transmission reported in any published studies.
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