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  • Title: Characterization of RNA aptamers against SRP19 protein having sequences different from SRP RNA.
    Author: Haraguchi Y, Kuwasako K, Muto Y, Bessho Y, Nishimoto M, Yokoyama S, Kanai A, Kawai G, Sakamoto T.
    Journal: Nucleic Acids Symp Ser (Oxf); 2009; (53):265-6. PubMed ID: 19749362.
    Abstract:
    SELEX is a conventional method to obtain high affinity nucleic acids to target molecules. In this study, high affinity RNA molecules against SRP19 protein were selected by using a randomized library. The primary and predicted secondary structures of the aptamers are different from those of S-domain RNA which is the natural target of SRP19 protein. Comparison of structural features between S-domain RNA and aptamers might enhance our understanding on RNA-protein interaction.
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