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  • Title: Upc2p-associated differential protein expression in Candida albicans.
    Author: Hoehamer CF, Cummings ED, Hilliard GM, Morschhäuser J, David Rogers P.
    Journal: Proteomics; 2009 Oct; 9(20):4726-30. PubMed ID: 19750515.
    Abstract:
    The gain-of-function mutation G648D in UPC2 causes ERG11 up-regulation and increased fluconazole resistance in Candida albicans. In this study, we performed 2-DE and PMF to identify proteomic alterations in an ERG11-overexpressing fluconazole-resistant C. albicans clinical isolate compared with its fluconazole-susceptible parent strain. We identified 23 differentially expressed proteins, and among them, seven became differentially expressed in a C. albicans wild-type strain after the introduction of a UPC2 allele carrying this mutation. These Upc2p-regulated proteins may contribute to fluconazole resistance in C. albicans.
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