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  • Title: T lymphocyte responses to heterologous secondary dengue virus infections.
    Author: Rothman AL.
    Journal: Ann N Y Acad Sci; 2009 Sep; 1171 Suppl 1():E36-41. PubMed ID: 19751400.
    Abstract:
    The available evidence suggests that plasma leakage in dengue hemorrhagic fever is caused by the action of circulating mediators on the vascular endothelium, and that the host immune response is a critical determinant of this response. We have been exploring the role of dengue virus-specific T lymphocytes in the immunopathogenesis of plasma leakage. Memory dengue virus-specific T cells induced during a primary dengue virus infection are reactivated by the heterologous viral serotype during a secondary infection to expand to high levels and produce a skewed cytokine profile. Investigations are underway to identify the immunologic profiles associated with increased or decreased risk for severe disease.
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