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  • Title: Sleep and health-related quality of life in heart failure.
    Author: Mills PJ, Dimsdale JE, Natarajan L, Ziegler MG, Maisel A, Greenberg BH.
    Journal: Congest Heart Fail; 2009; 15(5):228-33. PubMed ID: 19751424.
    Abstract:
    This study characterized sleep in heart failure (HF) and determined associations with quality of life. Forty stable HF patients and 34 healthy volunteers were studied in a clinical research unit. HF patients had more central apneas per hour (17.6 vs 5.4; P< or =.01) and obstructive apneas per hour (21.7 vs 8.5; P< or =.05), spent more time in stage 1 sleep (54 vs 35 min; P< or =.05), and had more respiratory awakenings following apneic events (27.2 vs 4.2; P< or =.01). More HF patients were depressed (55% vs 27.2%; P< or =.01) and had worse fatigue (P< or =.05). In multiple regression analysis, physical functioning quality of life was predicted by reduced left ventricular ejection fraction (P< or =.05), shorter distance on a 6-minute walk test (P< or =.05), greater fatigue (P< or =.01), and more apneas ( P< or =.05) (model R(2)=.672; P< or =.001). Emotional functioning quality of life was predicted by greater fatigue (P< or =.01) (model adjusted R(2)=.732; P<.001). Findings provide evidence that in addition to functional status and ongoing fatigue, poorer quality of life in HF is independently related to the severity of sleep-disordered breathing.
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