These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Studies on DNA markers (D4S10 and D4S43/S127) genetically linked to Huntington's disease in Japanese families.
    Author: Kanazawa I, Kondo I, Ikeda JE, Ikeda T, Shizu Y, Yoshida M, Narabayashi H, Kuroda S, Tsunoda H, Mizuta E.
    Journal: Hum Genet; 1990 Aug; 85(3):257-60. PubMed ID: 1975553.
    Abstract:
    This is the first full report on the genetic linkage between Japanese Huntington's disease and the DNA markers D4S10 and D4S43/S127. With use of the HindIII, BglI, and EcoRI polymorphisms detected at D4S10, and the combination of all these polymorphisms to give composite haplotypes, nine Japanese Huntington's disease families were found to be informative. Three recombinants for D4S10 were detected in these families, giving a maximum lod score of 1.662 at a theta of 0.10. Similarly, when we used the MspI and PvuII polymorphisms detected by D4S43/S127, five families gave informative results. No recombinant was detected in these families, giving a maximum lod score of 3.348 at a theta of 0.00. These results clearly support the view that the Japanese Huntington's disease gene may be identical with the Western gene, in spite of the lower prevalence rate in Japan.
    [Abstract] [Full Text] [Related] [New Search]