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  • Title: [Giant condyloma of the penis with malignant transformation associated with lichen sclerosus et atrophicus].
    Author: Wessendorf U, Bruch-Gerharz D, Braunstein S, Braunstein R, Schulte KW, Reifenberger J.
    Journal: Hautarzt; 2009 Oct; 60(10):787-9. PubMed ID: 19756435.
    Abstract:
    A 72-year old patient presented with a 6 months history of a rapidly growing tumor of the glans and foreskin. He had a long history of phimosis with lichen sclerosus et atrophicus-like lesions on the foreskin which had not been treated. The rest of the personal, family and sexual history was unremarkable. Treatment consists of circumcision and tumor excision. Histopathology confirmed a squamous cell carcinoma within a giant condyloma with a concomitant lichen sclerosus et atrophicus. CT- and ultrasound scans showed no metastases. Giant condylomas are a rare sexually transmitted disease usually caused by human papilloma virus subtypes 6, 11, but also by 16 and 18 among others. They are expansive, cauliflower-like destructive lesions that most frequently affect the anogenital region. In about 30 percent a giant condyloma progresses into a squamous cell carcinoma. Therapy of choice is the histopathologically controlled excision. Recurrences are often seen, so the patients should be monitored frequently after therapy.
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