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  • Title: Gamma-glutamyl transpeptidase and acetylcholinesterase activities in brain capillaries of cholesterol-fed rabbits.
    Author: Eryürek FG, Sürmen E, Oner P, Altuğ T, Oz H.
    Journal: Res Commun Chem Pathol Pharmacol; 1990 Aug; 69(2):245-8. PubMed ID: 1975702.
    Abstract:
    Cerebral microvascular endothelium, the constituent cell of the blood-brain barrier, is enriched in the enzyme gamma-glutamyl transpeptidase (GGT). This enzyme plays a role in the regulation of amino acid uptake and transport, and in the gamma-glutamylation of serotonin, dopamine and norepinephrine. Recent studies have demonstrated that GGT activity is modulated by cholinergic-adrenergic agonists. The levels of the acetylcholine-catabolizing enzyme acetylcholinesterase (AChE), may therefore be related to the modulation of the GGT activity. In this study, the activities of GGT and AChE in microvessel-enriched fractions were assayed after feeding of rabbits a high cholesterol diet. A 21% decrease of GGT activity and a 44% increase of AChE activity appeared at the end of dietary treatment.
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