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  • Title: [New diagnostic test for tuberculosis].
    Author: Ravn P, Rose MV, Søborg B, Andersen AB.
    Journal: Ugeskr Laeger; 2009 Sep 07; 171(37):2635-9. PubMed ID: 19758506.
    Abstract:
    The performance of two commercially-available Interferon Gamma Release Assays, QuantiFERON-TB-Gold and T-SPOT-TB, is reviewed. The tests can indirectly detect M. tuberculosis infection based on T-cell recognition of specific proteins which are not present in the BCG vaccine M. avium, or most other environmental mycobacteria.The sensitivity (76-88%) of the IGRAs is not optimal for a diagnostic test for active tuberculosis. However, the specificity is high (92-97%), and the IGRAs may play an important role in the investigation for active tuberculosis and screening for latent tuberculosis infection in BCG vaccinated populations and immunosuppressed patients.
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