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  • Title: Transfer of metyrapone and its metabolite, rac-metyrapol, into breast milk.
    Author: Hotham NJ, Ilett KF, Hackett LP, Morton MR, Muller P, Hague WM.
    Journal: J Hum Lact; 2009 Nov; 25(4):451-4. PubMed ID: 19759353.
    Abstract:
    Metyrapone, an inhibitor of corticosteroid biosynthesis, is used in the diagnosis and treatment of adrenocortical hyperfunction. The authors describe the excretion of metyrapone and its metabolite, rac-metyrapol, in milk from a lactating woman requiring metyrapone treatment (250 mg 4 times daily). At steady state, the average concentrations in milk and absolute and relative infant doses were 11 microg/L, 1.7 microg/kg/d, and 0.02%, respectively, for metyrapone, and 48.5 microg/L, 7.3 microg/kg/d, and 0.08%, respectively, for rac-metyrapol. The findings suggest that maternal metyrapone use during breastfeeding is extremely unlikely to be a significant risk for the breastfed infant.
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