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  • Title: Medetomidine- and medetomidine-ketamine-induced immobilization in blue foxes (Alopex lagopus) and its reversal by atipamezole.
    Author: Jalanka HH.
    Journal: Acta Vet Scand; 1990; 31(1):63-71. PubMed ID: 1975971.
    Abstract:
    The sedative and immobilizing effects of the alpha 2-adrenoceptor agonist medetomidine alone or combined with the dissociative anesthetic ketamine, were studied in blue foxes. Medetomidine at doses of 25 and 50 micrograms/kg induced moderate to deep sedation, but only with the highest medetomidine dose tested, 100 micrograms/kg, was the immobilization complete. Medetomidine 50 micrograms/kg combined with ketamine 2.5 mg/kg rapidly induced complete immobilization, characterized by good myorelaxation, and no clinically significant alterations in serially determined hematologic and serum chemistry parameters. The alpha 2-adrenoceptor antagonist atipamezole effectively reversed the medetomidine- or medetomidine-ketamine-induced immobilizations. A transient increase in heart rates was noted after each atipamezole injection. Medetomidin aliena eller i kombination med ketamin användes för immobilisering av blåräv. Med en dos på 20 och 50 μg/kg medetomidin, uppnåddes sedation. En fuliständig immobilisation och god mu-skelrelaxering uppnåddes med en dos på 100 μg/kg medetomidin och med 50 μg/kg medetomidin i kombination med 2.5 mg/kg ketamin. Atipamezol upphävde effektivt sedationen framkallad av medetomidin och medetomidin-ketamin.
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