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  • Title: WNT5A gene is aberrantly methylated from the early stages of colorectal cancers.
    Author: Hibi K, Mizukami H, Goto T, Kitamura Y, Sakata M, Saito M, Ishibashi K, Kigawa G, Nemoto H, Sanada Y.
    Journal: Hepatogastroenterology; 2009; 56(93):1007-9. PubMed ID: 19760930.
    Abstract:
    BACKGROUND/AIMS: Recently, it has been reported that WNT5A methylation was frequently detected in colorectal cancers. However, the relationship between the WNT5A methylation and the characteristics of these cancers remains unknown. METHODOLOGY: Methylation status of the WNT5A gene was examined in primary carcinomas and the corresponding normal tissues derived from 49 patients with colorectal cancer using quantitative methylation-specific PCR (qMSP) and the correlation between the methylation status and the clinicopathological findings was evaluated. RESULTS: Aberrant methylation of the WNT5A gene was detected in 17 out of the 49 (35%) primary colorectal cancers. The clinicopathological data were correlated with the methylation results. All stages of colorectal cancers presented WNT5A methylation. CONCLUSIONS: WNT5A gene has been methylated from the early stages of colorectal cancers.
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