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  • Title: Benzoyl peroxide: a review of its current use in the treatment of acne vulgaris.
    Author: Sagransky M, Yentzer BA, Feldman SR.
    Journal: Expert Opin Pharmacother; 2009 Oct; 10(15):2555-62. PubMed ID: 19761357.
    Abstract:
    BACKGROUND: Owing to the use of topical and systemic antibiotics for acne vulgaris, the incidence of antibiotic-resistant Propionibacterium acnes is increasing worldwide. Topical benzoyl peroxide (BPO) is an alternative to antibiotics in the treatment of acne vulgaris. OBJECTIVE: This review describes and evaluates recent clinical literature regarding the efficacy and tolerability of BPO. METHODS: A PubMed literature search was conducted using the keywords benzoyl peroxide, acne, and combination therapy. RESULTS: BPO is equally effective at concentrations of 2.5, 5.0 and 10%. However, a concentration-dependent irritant dermatitis can occur with higher concentrations. The efficacy of BPO can be enhanced when used in combination with topical retinoids, antibiotics and tertiary amines. BPO-containing combinations do not induce bacterial resistance and are important first-line treatments for mild to moderate acne vulgaris.
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