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  • Title: Somatostatin secretion and action in the regulation of growth hormone secretion.
    Author: Frohman LA, Downs TR, Kelijman M, Clarke IJ, Thomas G.
    Journal: Metabolism; 1990 Sep; 39(9 Suppl 2):43-5. PubMed ID: 1976219.
    Abstract:
    The inhibition of growth hormone (GH) secretion by the hypothalamic peptide, somatostatin, is mediated by two critical factors: the concentration of the peptide in hypothalamic portal plasma and the number of somatostatin (SRIF) receptors on the somatotroph. The secretory patterns of SRIF and GH-releasing hormone (GRH) in portal blood of unanesthetized sheep is pulsatile and a close relationship of GRH pulses to those of GH secretion was documented, while those of SRIF appear to have more of a modulatory role on the responses to GRH. Peripheral infusion of SRIF at a rate to provide concentrations comparable to those in the portal system leads to a desensitization of SRIF effects on the somatotroph, likely mediated by down-regulation of SRIF receptors. These effects are believed to modulate the GH responses to GRH secretion in the generation of pulsatile GH secretion.
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