These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: An accurate diagnosis of Noguchi classification is possible after the modification of preoperative biopsy-induced fibrosis.
    Author: Nakajima Y, Kawamoto M, Koizumi K, Tajima H, Fukuda Y, Tsuchiya S, Shimizu K.
    Journal: Ann Thorac Cardiovasc Surg; 2009 Aug; 15(4):221-6. PubMed ID: 19763052.
    Abstract:
    PURPOSE: After computed-tomography-guided needle biopsy (CTNB), the lung may undergo iatrogenic fibrosis (post-CTNB fibrosis), which can be misdiagnosed as tumor-induced fibrosis. The purpose of the study was to examine if an accurate evaluation of pulmonary adenocarcinoma can be made using the Noguchi classification (type A or B vs. type C), even after CTNB. MATERIALS AND METHODS: The subjects were 71 patients with primary pulmonary adenocarcinoma of 20 mm or less that had been resected surgically after CTNB. Twenty-four patients who did not undergo a preoperative biopsy served as controls. Resected specimens were stained with hematoxylin-eosin (HE) and elastic-fiber staining for a precise observation of fibrosis. RESULTS: The period from CTNB to surgery ranged from 12 to 153 days. Post-CTNB fibrosis consisted primarily of collagen fibers with a few thin elastic fibers observed only with high magnification, which was able to distinguish post-CTNB fibrosis in 39 of 48 patients (81.3%) with bronchioloalveolar carcinoma (BAC) lesions (types A/B/C) and in 6 of 23 patients (26.1%) without BAC lesions (types D/E/F/E + F), showing a significant difference (p <0.0001). In the control group, no lesions that resembled post-CTNB fibrosis were observed. CONCLUSION: An evaluation of pulmonary adenocarcinoma by Noguchi classification can be accurately performed even after CTNB.
    [Abstract] [Full Text] [Related] [New Search]