These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: A gorge-spanning, high-affinity cholinesterase inhibitor to explore beta-amyloid plaques.
    Author: Elsinghorst PW, Härtig W, Goldhammer S, Grosche J, Gütschow M.
    Journal: Org Biomol Chem; 2009 Oct 07; 7(19):3940-6. PubMed ID: 19763296.
    Abstract:
    Cholinesterases are involved in the pathological formation of beta-amyloid plaques. To investigate this pathohistological hallmark of Alzheimer's disease we prepared a high-affinity, fluorescent cholinesterase inhibitor. Its fluorescence intensity was significantly enhanced upon binding to cholinesterases. Using this probe, brain samples from mice and humans affected by Alzheimer's disease were successfully analyzed for beta-amyloid plaques. Unexpectedly, it was discovered, by competition experiments, that the compound binds to amyloid structures, rather than to cholinesterases inside of the plaques.
    [Abstract] [Full Text] [Related] [New Search]