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  • Title: Homophymines B-E and A1-E1, a family of bioactive cyclodepsipeptides from the sponge Homophymia sp.
    Author: Zampella A, Sepe V, Bellotta F, Luciano P, D'Auria MV, Cresteil T, Debitus C, Petek S, Poupat C, Ahond A.
    Journal: Org Biomol Chem; 2009 Oct 07; 7(19):4037-44. PubMed ID: 19763308.
    Abstract:
    Nine new cyclodepsipeptides, homophymines B-E (2-5) and A1-E1 (1a-5a), were isolated from the polar extracts of the sponge Homophymia sp. The new structures, featuring new polyketide-derived end groups, were determined by interpretation of NMR and MS data. The configurations of the new end groups was secured by the application of J-based configurational analysis. Homophymines displayed very potent antiproliferative activity (IC(50) in the nM range) against a panel of human cancer cell lines.
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