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  • Title: [Long-term histological outcome for the larynx after Gore-Tex medialization thyroplasty].
    Author: Sasai H, Watanabe Y, Miyahara H.
    Journal: Nihon Jibiinkoka Gakkai Kaiho; 2009 Aug; 112(8):623-7. PubMed ID: 19764545.
    Abstract:
    OBJECTIVES: We studied the long-term histological response of the human larynx to Gore-Tex implant and evaluated whether its biocompatibility. STUDY DESIGN: Retrospective histological study. METHODS: We conducted medialization laryngoplasty with expanded polytetrafluoroethylene (ePTEE or Gore-Tex) in a patient with vocal-fold paralysis. A strip of Gore-Tex was folded several times and inserted into the pocket preserving the inner perichondrium through a thyroid cartilage window. The patient died 12 months later and we histologically analyzed the larynx. RESULTS: No evidence was seen of foreign body granuloma, migration, extrusion, or infection. A modest inflammatory response with a fibrous capsule was present around implants. We confirmed the infiltration of abundant collagen and numerous fibroblasts into the microporous implant structure. CONCLUSION: Histological examination results suggest that Gore-Tex implants are safe and biocompatible with the human larynx. A slight inflammatory response and infiltration of fibrous tissue into the implant itself demonstrated that Gore-Tex implants are immunologically well tolerated.
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