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  • Title: [Expression of HSP60, TLR4 and NF-kappaBp65 in the peripheral blood of patients with atopic dermatitis].
    Author: Gao Y, Guo ZP.
    Journal: Sichuan Da Xue Xue Bao Yi Xue Ban; 2009 Jul; 40(4):655-7. PubMed ID: 19764566.
    Abstract:
    OBJECTIVE: To investigate the expressions of HSP60, TLR4 and NF-kappaBp65 in the peripheral blood of patients with atopic dermatitis (AD) and their roles in the pathogenesis of AD. METHODS: RT-PCR, immunocytochemistry and ELISA were performed to measure the mRNA expressions of TLR4 and NF-kappaBp65 in the peripheral lymphocytes and monocytes, and the serum HSP60, respectively. A total of 17 patients with AD were recruited for the study, with 15 healthy people serving as controls. RESULTS: The levels of HSP60, TLR4 mRNA and NF-kappaBp65 were significantly higher in the peripheral blood of the patients with AD than in the controls (P<0.05). CONCLUSION: HSP60, TLR4 and NF-kappaBp65 are overexpressed in the peripheral blood of patients with AD, which might be associated with the pathogenesis of AD.
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