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  • Title: Localization and polymorphism of a chromosome 12-specific alpha satellite DNA sequence.
    Author: Looijenga LH, Smit VT, Wessels JW, Mollevanger P, Oosterhuis JW, Cornelisse CJ, Devilee P.
    Journal: Cytogenet Cell Genet; 1990; 53(4):216-8. PubMed ID: 1976486.
    Abstract:
    The isolation and localization of a chromosome 12-specific alpha satellite DNA sequence, p alpha 12H8, is described. This clone contains a complete copy of the 1.4-kb HindIII higher-order repeat present within the alpha satellite array on chromosome 12. The specificity of p alpha 12H8 was demonstrated by in situ hybridization and Southern blot analysis of a somatic cell hybrid mapping panel, both performed under high-stringency conditions. Polymorphic restriction patterns within the alpha satellite array, revealed by the use of the restriction enzymes BglII and EcoRV, were demonstrated to display Mendelian inheritance. These properties make p alpha 12H8 a valuable genetic marker for the centromeric region of chromosome 12.
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