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  • Title: In vivo selection of carbapenem-resistant Klebsiella pneumoniae by OmpK36 loss during meropenem treatment.
    Author: Song W, Suh B, Choi JY, Jeong SH, Jeon EH, Lee YK, Hong SG, Lee K.
    Journal: Diagn Microbiol Infect Dis; 2009 Dec; 65(4):447-9. PubMed ID: 19766430.
    Abstract:
    We recovered a carbapenem-resistant Klebsiella pneumoniae isolate H224 under in vivo meropenem selection pressure. Insertional inactivation of a major porin gene, ompK36, by IS5 element might play a role in acquiring carbapenem resistance in this strain harboring plasmid-borne DHA-1 AmpC beta-lactamase.
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