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  • Title: Impedance spectroscopy of human erythrocyte membrane: effect of frequency at the spectrin denaturation transition temperature.
    Author: Ivanov IT.
    Journal: Bioelectrochemistry; 2010 Jun; 78(2):181-5. PubMed ID: 19767250.
    Abstract:
    Thermal analysis of suspension impedance was applied at various frequencies, f, to study the changes in erythrocyte membranes (EM) over the temperature interval 47-53 degrees C where spectrin denatures. At f<crossover frequency (cof1) a decrease in EM resistance at 49.5 degrees C (A peak) has been observed. At f>cof1, when the capacitive conductance of EM becomes dominant, a second peak appeared at 50.5 degrees C (anti-A peak). The amplitudes of A and anti-A peaks reversibly depended on the phosphorylation of EM proteins. In contrast to the A peak, the anti-A peak was totally eliminated by modifications of EM with reagents that reduce EM deformability, O(s)O(4) (0.4-1mM) and putrescine (cytosolic concentration 1.5-2.0mM).
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