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  • Title: The selectivity of the opioid antagonist, naltrindole, for delta-opioid receptors.
    Author: Rogers H, Hayes AG, Birch PJ, Traynor JR, Lawrence AJ.
    Journal: J Pharm Pharmacol; 1990 May; 42(5):358-9. PubMed ID: 1976787.
    Abstract:
    In the mouse vas deferens, naltrindole gave pKB values of 9.7, 8.3, and 7.5 at the delta-, mu-, and kappa-sites and in binding assays, pIC50 values of 9.6, 7.8 and 7.2 at the same sites. The affinity of naltrindole for the delta binding site was increased in the presence of sodium ions and 5'-guanylylimidophosphate. Naltrindole is, thus, a potent opioid antagonist with marked selectivity for the delta-opioid receptor.
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