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  • Title: A versatile approach for assaying in vitro metallodrug metabolism using CE hyphenated with ICP-MS.
    Author: Abramski JK, Foteeva LS, Pawlak K, Timerbaev AR, Jarosz M.
    Journal: Analyst; 2009 Oct; 134(10):1999-2002. PubMed ID: 19768206.
    Abstract:
    An informative analytical method, based on commercially available capillary electrophoresis (CE), inductively coupled plasma mass spectrometry (ICP-MS) and interface units, was developed for ascertaining possible metabolic transformations of metal-based drugs. Using a novel anticancer gallium compound, it was demonstrated that the drug remains intact in the simulated intestine juice. On the contrary, it undergoes a marked change in speciation (mostly, due to binding to transferrin) in human serum.
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