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  • Title: [Molecular mechanisms of insomnia].
    Author: Urade Y.
    Journal: Nihon Rinsho; 2009 Aug; 67(8):1489-93. PubMed ID: 19768929.
    Abstract:
    Prostaglandin (PG) D2 and adenosine are potent endogenous somnogens and their sleep-inducing mechanisms are well characterized. We examined the contribution of these somnogens to physiological sleep by the combination of pharmacological tools and gene-knockout (KO) mice. Complete insomnia was observed in wild-type mice after an intraperitoneal injection of SeCl4, an inhibitor of PGD synthase (PGDS), or caffeine, an antagonist of adenosine A2A receptors. The SeCl4-induced insomnia was not observed in PGDS- or DP1 receptor-KO mice and the caffeine-induced insomnia, in A(2A) receptor-KO mice. A DP1 antagonist, ONO-4127Na, reduced sleep of rats by 30% during infusion into the subarachnoid space of the basal forebrain. These results indicate that the PGD2/ adenosine system plays a critical role in the regulation of physiological sleep.
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