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  • Title: Synthesis of the monomeric counterpart of marinomycin A.
    Author: Amans D, Bareille L, Bellosta V, Cossy J.
    Journal: J Org Chem; 2009 Oct 16; 74(20):7665-74. PubMed ID: 19769335.
    Abstract:
    An efficient and highly convergent synthesis of the monomeric counterpart of the antitumor-antibiotic marine natural product marinomycin A was achieved by using optically active titanium complexes to control the configuration of the stereogenic centers, a highly stereo- and regioselective cross-metathesis to generate the (E)-configured C20-C21 double bond, and a Horner-Wadsworth-Emmons olefination followed by a Pd-catalyzed Stille cross-coupling to construct the tetraene moiety.
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