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  • Title: Dwarf locus mutants lacking three pituitary cell types result from mutations in the POU-domain gene pit-1.
    Author: Li S, Crenshaw EB, Rawson EJ, Simmons DM, Swanson LW, Rosenfeld MG.
    Journal: Nature; 1990 Oct 11; 347(6293):528-33. PubMed ID: 1977085.
    Abstract:
    Mutations at the mouse dwarf locus (dw) interrupt the normal development of the anterior pituitary gland, resulting in the loss of expression of growth hormone, prolactin and thyroid-stimulating hormone, and hypoplasia of their respective cell types. Disruptions in the gene encoding the POU-domain transcription factor, Pit-1, occur in both characterized alleles of the dwarf locus. The data indicate that Pit-1 is necessary for the specification of the phenotype of three cell types in the anterior pituitary, and directly link a transcription factor to commitment and progression events in mammalian organogenesis.
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