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  • Title: [Protective effect of 3'-methoxy puerarin on cerebral ischemic injury/ reperfusion in rats].
    Author: Han J, Wan H, Ge L, Zhu Z, Guo Y, Zhang Y, Li J.
    Journal: Zhongguo Zhong Yao Za Zhi; 2009 Jun; 34(11):1422-5. PubMed ID: 19771877.
    Abstract:
    OBJECTIVE: To observe the effect of 3'-methoxy puerarin on cerebral infarction volume and free radical change of focal cerebral ischemia-reperfusion injury in rats and discuss the protective effect of 3'-methoxy puerarin on the cerebral ischemic/ reperfusion injury. METHOD: The thread method was used to induce middle cerebral artery embolization, to establish the focal cerebral ischemia-reperfusion model. Rats were divided into five groups: the sham and model group, the two-dose group (5, 10 mg x kg(-1) x d(-1)) of 3'-methoxy puerarin and nimodipine group (5 mg x kg(-1) x d(-1)). The behavior changes and volume of cerebral infarction were observed, and the leves of SOD and the content of MDA were measured. RESULT: 3'-methoxy puerarin could significantly improve the symptoms of neurological deficit and reduce the infarct volume, and increased SOD activity and reduced the content of MDA of cortex in cerebral ischemia-reperfusion injury rat, the action of 10 mg x kg(-1) of 3'-methoxy puerarin is more remarkable. CONCLUSION: 3'-methoxy puerarin has protective effect on focal cerebral ischemia-reperfusion injury in rat.
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