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  • Title: An extremely facile synthesis of furans, pyrroles, and thiophenes by the dehydrative cyclization of propargyl alcohols.
    Author: Aponick A, Li CY, Malinge J, Marques EF.
    Journal: Org Lett; 2009 Oct 15; 11(20):4624-7. PubMed ID: 19772313.
    Abstract:
    Furans, pyrroles, and thiophenes are efficiently prepared by gold-catalyzed dehydrative cyclizations of readily available, heteroatom-substituted propargylic alcohols. The reactions are rapid, high-yielding, and procedurally simple, giving essentially pure aromatic heterocycles in minutes under open-flask conditions with catalyst loadings as low as 0.05 mol %.
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