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  • Title: Efficient synthesis of nevirapine analogs to study its metabolic profile by click fishing.
    Author: Bernard S, Defoy D, Dory YL, Klarskov K.
    Journal: Bioorg Med Chem Lett; 2009 Nov 01; 19(21):6127-30. PubMed ID: 19773166.
    Abstract:
    Knowledge of the biotransformation and pharmacokinetics of the antiretroviral agent nevirapine is still insufficient. In order to trace rash inducing metabolites of nevirapine, we devised a short and efficient multi-gram synthesis of a nevirapine analog that can be coupled to azide containing compounds by click chemistry.
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