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  • Title: Organic reactions in water: a distinct novel approach for an efficient synthesis of alpha-amino phosphonates starting directly from nitro compounds.
    Author: Das B, Satyalakshmi G, Suneel K, Damodar K.
    Journal: J Org Chem; 2009 Nov 06; 74(21):8400-2. PubMed ID: 19775086.
    Abstract:
    A distinct approach for high-yielding synthesis of alpha-amino phosphonates has been discovered through three-component reaction of nitro compounds, aldehydes, or ketones and dialkyl or trialkyl phosphites using indium in dilute aqueous HCl at room temperature. This one-pot conversion consists of the following steps: (i) reduction of nitro compounds to amines, (ii) formation of imines from amines and carbonyl compounds, and (iii) hydrophosphonylation of imines.
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