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  • Title: Monoterpenoid indole alkaloids from Alstonia yunnanensis.
    Author: Feng T, Li Y, Cai XH, Gong X, Liu YP, Zhang RT, Zhang XY, Tan QG, Luo XD.
    Journal: J Nat Prod; 2009 Oct; 72(10):1836-41. PubMed ID: 19775092.
    Abstract:
    Eight new monoterpenoid indole alkaloids, alstoyunines A-H (1-8), along with 17 known analogues, were isolated from Alstonia yunnanensis. The structures of the new alkaloids were established by means of extensive spectroscopic methods. Alstoyunines C (3), E (5), and F (6) showed selective inhibition of Cox-2 (>75%). Alstoyunine F (6) showed weak cytotoxicity against the human myeloid leukemia HL-60 (IC50 = 3.89 microM) and hepatocellular carcinoma SMMC-7721 (IC50 = 21.73 microM) cell lines.
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