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  • Title: Total synthesis of the antiproliferative macrolide (+)-neopeltolide.
    Author: Guinchard X, Roulland E.
    Journal: Org Lett; 2009 Oct 15; 11(20):4700-3. PubMed ID: 19775106.
    Abstract:
    A concise total synthesis of the very promising antiproliferative macrolide (+)-neopeltolide (1) has been performed in 16 steps. The main steps of this approach are a Ru(II)-catalyzed alkyne-enal coupling, a Pd0-catalyzed desulfurative cross-coupling, and a stereoselective In(III)-catalyzed propargylation. Four stereogenic centers out of six have been set thanks to substrate-controlled diastereoselective reactions with minimal reliance on protecting groups.
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