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  • Title: Production of tylosin in solid-state fermentation by Streptomyces fradiae NRRL-2702 and its gamma-irradiated mutant (gamma-1).
    Author: Khaliq S, Rashid N, Akhtar K, Ghauri MA.
    Journal: Lett Appl Microbiol; 2009 Nov; 49(5):635-40. PubMed ID: 19780953.
    Abstract:
    AIMS: To develop solid-state fermentation system (SSF) for hyper production of tylosin from a mutant gamma-1 of Streptomyces fradiae NRRL-2702 and its parent strain. METHODS AND RESULTS: Various agro-industrial wastes were screened to study their effect on tylosin production in SSF. Wheat bran as solid substrate gave the highest production of 2500 microg of tylosin g(-1) substrate by mutant gamma-1 against parent strain (300 microg tylosin g(-1) substrate). The tylosin yield was further improved to 4500 microg g(-1) substrate [70% moisture, 10% inoculum (v/w), pH 9.2, 30 degrees C, supplemental lactose and sodium glutamate on day 9]. Wild-type strain displayed less production of tylosin (655 microg of tylosin g(-1) substrate) in SSF even after optimization of process parameters. CONCLUSION: The study has shown that solid-state fermentation system significantly enhanced the tylosin yield by mutant gamma-1. SIGNIFICANCE AND IMPACT OF THE STUDY: This study proved to be very useful and resulted in 6.87 +/- 0.30-fold increase in tylosin yield by this mutant when compared to that of wild-type strain.
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