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  • Title: Fabrication of a novel impedance cell sensor based on the polystyrene/polyaniline/Au nanocomposite.
    Author: Gu M, Zhang J, Li Y, Jiang L, Zhu JJ.
    Journal: Talanta; 2009 Nov 15; 80(1):246-9. PubMed ID: 19782222.
    Abstract:
    Gold nanoparticles (AuNPs) were assembled on the surface of polystyrene (PS) and polyaniline (PANI) core-shell nanocomposite (PS@PANI) for the immobilization of HL-60 leukemia cells to fabricate a cell electrochemical sensor. The immobilized cells exhibited irreversible voltammetric response and increased the electron transfer resistance with a good correlation to the logarithmic value of concentration ranging from 1.6 x 10(3) to 1.6 x 10(8) cells mL(-1) with a limit of detection of 7.3 x 10(2) cells mL(-1) at 10 sigma. This biosensor was simple, low cost and disposable, which implied that the PS@PANI/Au composites can regard as the potential applications for clinical applications.
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