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  • Title: Effects of dexmedetomidine on contractility, relaxation, and intracellular calcium transients of isolated ventricular myocardium.
    Author: Housmans PR.
    Journal: Anesthesiology; 1990 Nov; 73(5):919-22. PubMed ID: 1978616.
    Abstract:
    The effects of the highly selective alpha 2-adrenoceptor agonist dexmedetomidine on contractility, relaxation, and the intracellular Ca2+ transients of isolated ventricular myocardium were studied in isolated right ventricular papillary muscles obtained from reserpinized ferrets. Dexmedetomidine (10(-10)-10(-5) M) did not alter amplitude and time variables of isometric, isotonic and zero-load-clamped twitches, except for a slight increase in maximal isotonic relaxation rate at 10(-5) M. Dexmedetomidine (10(-8)-10(-5) M) caused no changes in the intracellular Ca2+ transient detected with aequorin. These results suggest that dexmedetomidine has no intrinsic myocardial contractile effects.
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