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  • Title: Bioactivity of flavonoids isolated from Lychnophora markgravii against Leishmania amazonensis amastigotes.
    Author: Salvador MJ, Sartori FT, Sacilotto AC, Pral EM, Alfieri SC, Vichnewski W.
    Journal: Z Naturforsch C J Biosci; 2009; 64(7-8):509-12. PubMed ID: 19791501.
    Abstract:
    The bioactivity of the flavonoids pinostrobin (1), pinocembrin (2), tectochrysin (3), galangin 3-methyl ether (4), and tiliroside (5) isolated from Lychnophora markgravii aerial parts was investigated in vitro against amastigote stages of Leishmania amazonensis. The compounds were isolated by several chromatographic techniques and their chemical structures were established by ESI-MS and NMR spectroscopic data. The flavonoids 1 and 3 were the most active compounds; they markedly reduced the viability of Leishmania amastigotes.
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