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  • Title: Body temperature discriminates between full and partial benzodiazepine receptor agonists.
    Author: Jackson HC, Nutt DJ.
    Journal: Eur J Pharmacol; 1990 Aug 28; 185(2-3):243-6. PubMed ID: 1979276.
    Abstract:
    The benzodiazepine full agonist loprazolam and the beta-carboline ZK 93423 produced hypothermia in mice (1-30 mg/kg i.p.). Maximal effects were seen at relatively low doses of these compounds. In contrast, the partial agonists Ro 17-1812 (a benzodiazepine) and ZK 91296 (a beta-carboline), did not modify rectal temperature at doses up to 30 mg/kg i.p. (which would be receptor saturating). Body temperature may therefore be a useful test for discriminating between full and partial agonists at the benzodiazepine receptor.
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