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  • Title: Predicting therapy outcome in patients with early and late obsessive-compulsive disorder (EOCD and LOCD).
    Author: Langner J, Laws M, Röper G, Zaudig M, Hauke W, Piesbergen C.
    Journal: Behav Cogn Psychother; 2009 Oct; 37(5):485-96. PubMed ID: 19796435.
    Abstract:
    BACKGROUND: Increasing attention has been given to subtyping OCD with respect to different clinical profiles, response to drug treatments, comorbidity and age of onset. There are a number of studies looking at predictors of treatment outcome in OCD, but so far not for OCD subtypes. METHOD: Prediction of outcome after cognitive-behavioural therapy was evaluated in 63 inpatients with early obsessive-compulsive disorder (EOCD < or = 12 years of age) and 191 patients with late obsessive-compulsive disorder (LOCD > 15 years of age). RESULTS: For EOCD patients factors predicting a good outcome included high motivation and high initial Y-BOCS scores. Factors associated with a bad outcome were higher age at assessment, a longer duration of psychiatric inpatient treatment before assessment and a low level of social functioning (BSS). For LOCD patients living in a stable relationship, high motivation and completing treatment predicted a favourable therapy outcome, while a low level of psychological functioning (BSS) and a longer duration of inpatient psychiatric treatment before assessment were associated with an undesirable therapy outcome. CONCLUSIONS: Subtyping OCD patients according to age of onset seems to be a promising avenue towards improving and developing more specified treatment programs.
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