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  • Title: Model to predict endothelial cell loss after iris-fixated phakic intraocular lens implantation.
    Author: Doors M, Berendschot TT, Webers CA, Nuijts RM.
    Journal: Invest Ophthalmol Vis Sci; 2010 Feb; 51(2):811-5. PubMed ID: 19797204.
    Abstract:
    PURPOSE: To describe a model predicting endothelial cell (EC) loss after iris-fixated phakic intraocular lens (pIOL) implantation, taking distance from the edge of the pIOL to the endothelium into account. METHODS: This prospective observational study monitored long-term EC changes in 306 eyes after pIOL implantation. EC density (ECD) was determined before surgery, 6 months after surgery, and then annually up to 8 years after surgery. Mean follow-up was 31.7 +/- 25.7 months. All eyes underwent anterior segment optical coherence tomography to determine minimum distance from the edge of the pIOL to the endothelium. Linear mixed-model analysis was performed to present a model that describes EC loss as a linear decrease and an additional decrease depending on the postoperative edge distance of the patient. RESULTS: Mean minimum edge distance was 1.43 +/- 0.23 mm (range, 0.70-2.21 mm). For this mean edge distance, the model predicted a yearly EC loss of 1.0%, whereas an edge distance of 1.20 mm resulted in a yearly EC loss of 1.7%, and an edge distance of 1.66 mm led to a yearly EC loss of only 0.2%. Furthermore, the model predicted that for patients with preoperative ECDs of 3000, 2500 or 2000 cells/mm(2), and edge distances of 1.43 mm, a critical ECD of 1500 cells/mm(2) (at which point pIOL explantation and cataract extraction can still safely be performed) will be reached at 56, 37, and 18 years after implantation. CONCLUSIONS: The presented model predicts EC loss after iris-fixated pIOL implantation in relation to the measured edge distance, patient age, and preoperative ECD, which can assist ophthalmologists in patient selection and follow-up of pIOLs.
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