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  • Title: Facile synthesis of 1,2,4-triazoles via a copper-catalyzed tandem addition-oxidative cyclization.
    Author: Ueda S, Nagasawa H.
    Journal: J Am Chem Soc; 2009 Oct 28; 131(42):15080-1. PubMed ID: 19799379.
    Abstract:
    A simple one-step synthesis of 1,2,4-triazole derivatives is provided by a copper-catalyzed oxidative coupling reaction under an atmosphere of air. The process should consist of sequential N-C and N-N bond-forming copper-catalyzed oxidative coupling reactions. Starting materials and the copper catalyst are readily available and inexpensive. A wide range of functional groups are tolerated to achieve chemical diversity.
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