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  • Title: Betamethasone dose and formulation for induced lung maturation in fetal sheep.
    Author: Jobe AH, Nitsos I, Pillow JJ, Polglase GR, Kallapur SG, Newnham JP.
    Journal: Am J Obstet Gynecol; 2009 Dec; 201(6):611.e1-7. PubMed ID: 19800603.
    Abstract:
    OBJECTIVE: We hypothesized that maternal treatments with betamethasone acetate induce fetal lung maturation comparably to the betamethasone phosphate+betamethasone acetate used clinically. STUDY DESIGN: Ewes with singleton pregnancies were treated with single doses of 0.25-mg/kg or 0.5-mg/kg betamethasone acetate, 4 doses of 0.25-mg/kg betamethasone phosphate, a single dose of 0.5-mg/kg betamethasone acetate+0.25-mg/kg betamethasone phosphate, 2 doses of 0.25-mg/kg betamethasone acetate+0.25-mg betamethasone phosphate or vehicle beginning 48 hours before preterm delivery. Fetal lung maturation was evaluated. RESULTS: All treatments induced lung maturation relative to vehicle controls. The relatively insoluble betamethasone acetate resulted in low maternal blood betamethasone and no detectable fetal blood betamethasone in 2 of 3 fetuses, but it induced fetal lung maturation comparable to the 2-dose betamethasone acetate+betamethasone phosphate or 4 doses of betamethasone phosphate. CONCLUSION: A single maternal dose of betamethasone acetate effectively induces fetal lung maturation in sheep with minimal fetal exposure.
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