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  • Title: New friedelane triterpenoids with antimicrobial activity from the stems of Drypetes paxii.
    Author: Chiozem DD, Trinh-Van-Dufat H, Wansi JD, Mbazoa Djama C, Fannang VS, Seguin E, Tillequin F, Wandji J.
    Journal: Chem Pharm Bull (Tokyo); 2009 Oct; 57(10):1119-22. PubMed ID: 19801870.
    Abstract:
    Two new friedelane-type triterpenes named 12alpha-hydroxyfriedelane-3,15-dione and 3beta-hydroxyfriedelan-25-al, together with six known compounds were isolated from the stems of Drypetes paxii Hutch. (Euphorbiaceae). Their structures were established on the basis of conventional 1 dimensional (1D) NMR methods, 2D shift-correlated NMR experiments and mass spectra. The five friedelane-type triterpene derivatives and one olean-12-ene triterpene saponin were tested for antimicrobial activity against some gram-positive and gram-negative bacteria, and they appeared to be modestly active.
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