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  • Title: [Effect of persistent pollutants on the rat liver antioxidant status].
    Author: Agletdinov EF, Nikonorov AA, Kamilov FKh.
    Journal: Gig Sanit; 2009; (4):66-8. PubMed ID: 19802951.
    Abstract:
    The hepatic antioxidant status was studied in the rats poisoned by a Sovol mixture of polychlorobiphenyls in different doses. Exposure to the toxic agent in a dose of 600 mg/kg leads to the accumulation of peroxidation products, the drop of reduced gluthatione, NADPH and the suppressed activities of superoxide dismutase, catalase, glutathione peroxidase, and glutathione-S-transferase. The findings suggest that severe oxidant stress develops in liver tissue, which may be one of the leading mechanisms responsible for the toxicity of biphenyls.
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