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  • Title: Use of ceftazidime in severe Gram-negative infections--a preliminary study.
    Author: Clumeck N, Vanlaethem Y, Gordts B, Jaspar N, Butzler JP.
    Journal: J Antimicrob Chemother; 1981 Sep; 8 Suppl B():317-21. PubMed ID: 19803007.
    Abstract:
    Ceftazidime was used to treat ten patients with serious Gram-negative bacillary infections. Seven patients had bronchopulmonary infections and three had urinary tract infections. In addition three patients were bacteraemic. Causative agents were: Pseudomonas aeruginosa 4, Escherichia coli 2, Proteus species 2, and Klebsiella pneumoniae 2. Doses ranged between 2 and 6 g/day. Nine out of ten patients responded favourably to ceftazidime (cure or improvement). Colonization with ceftazidime-resistant strains occurred in three cases. No evidence of nephrotoxicity was noted.
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