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Title: Somatostatin content and binding in small intestinal mucosa from fed, fasted, and refed rabbits. Author: Roca B, Fernandez-Valencia R, Rodríguez-Sánchez MN, Arilla E. Journal: Life Sci; 1990; 47(22):2041-9. PubMed ID: 1980331. Abstract: The present study is an investigation of the effects of 12- to 96-hours' starvation and 96-hours' starvation plus 48-hours' refeeding on both somatostatin-like immunoreactivity (SLI) and cytosolic somatostatin binding sites in rabbit small intestinal mucosa. The SLI concentration increased after 24 h in duodenal and jejunal mucosa, but not in ileal mucosa, and reached its highest value after 96 h of fasting. The number of specific high and low-affinity somatostatin binding sites, but not their affinity, decreased with the duration of fasting in the same gut segments, refeeding of fasted animals resulted in a return to normal control values for small intestine mucosal SLI and somatostatin binding.[Abstract] [Full Text] [Related] [New Search]