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Title: Total synthesis of amphidinolide Q. Author: Hangyou M, Ishiyama H, Takahashi Y, Kobayashi J. Journal: Org Lett; 2009 Nov 05; 11(21):5046-9. PubMed ID: 19803529. Abstract: Asymmetric synthesis of amphidinolide Q, a cytotoxic macrolide from the cultured dinoflagellate Amphidinium sp., has been accomplished with Julia coupling, Myers alkylation, and Yamaguchi lactonization. The absolute configuration of amphidinolide Q was confirmed to be 1 from comparison of the NMR data and [alpha](D) values of synthetic and natural amphidinolide Q.[Abstract] [Full Text] [Related] [New Search]