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  • Title: Aspartic acid release from cerebral cortical slices of E1 mice with high seizure susceptibility.
    Author: Higashihara Y, Hiramatsu M, Mori A.
    Journal: Res Commun Chem Pathol Pharmacol; 1990 Nov; 70(2):155-71. PubMed ID: 1980543.
    Abstract:
    Unlike their parent strain ddY mice, inbred mutant E1 mice are highly susceptible to convulsive seizures upon tossing stimulation. The uptake and release of [3H]aspartate by cerebral neocortical slices were investigated in non-stimulated E1 mice [E1(-)], in stimulated E1 mice [E1(+)] and also in ddY mice using a superfusion system. The uptake and release of aspartate in E1(-) were lower than in E1(+) or ddY. However, the aspartate level in the cerebral cortex of E1(-) was higher compared to that of E1(+) or ddY. Addition of aspartate into the medium resulted to a decreased potassium-stimulated aspartate release in ddY, an increased in E1(-), and no change in E1(+). The results suggest that abnormal state of aspartate release and/or uptake in cerebral cortex of E1 mice may contribute to their increased susceptibility of seizures.
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