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  • Title: [Genetic polymorphisms of 9 non-combined of DNA index system short tandem repeat loci in Guangdong Han population].
    Author: Zhang JX, Xue TY, Li HX, Sun HY, Cheng JD.
    Journal: Zhonghua Yi Xue Yi Chuan Xue Za Zhi; 2009 Oct; 26(5):580-4. PubMed ID: 19806587.
    Abstract:
    OBJECTIVE: To investigate the genetic polymorphisms and their forensic application of 9 non-combined of DNA index system (CODIS) short tandem repeat(STR) loci in Guangdong Han population. METHODS: DNA samples from 500 unrelated individuals were extracted and amplified with fluorescence labeled multiplex PCR system. PCR products were separated and genotyped with capillary electrophoresis. RESULTS: One hundred and fifteen alleles and 160 genotypes were observed in the 9 STR loci, respectively. The heterozygosity was 0.824-0.884, the discrimination power (DP) was 0.925-0.969 and the polymorphism information content (PIC) was 0.77-0.86, respectively. The distribution met the Hardy-Weinberg equilibrium (P > 0.05). The total discrimination power was 1.00 x 10(-13), the combined probability of exclusion for trio-paternity testing was 0.999989488. The combined probability of exclusion for duo-paternity testing was 0.873436. CONCLUSION: The 9 STR loci are powerful and reliable for personal identification and paternity testing. They can be used as supplementary loci in fatherless (motherless) testing or cases with mutation events.
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