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  • Title: [Synthesis and in vitro cytotoxicity of naphthalimide polyamine conjugates as antitumor agents].
    Author: Mei ZH, Tian ZY, Ma HX, Xie SQ, Zhao J, Wang CJ.
    Journal: Yao Xue Xue Bao; 2009 Jul; 44(7):754-7. PubMed ID: 19806915.
    Abstract:
    Six naphthalimide polyamine conjugates were synthesized and their structures were confirmed by elemental analysis, 1H NMR, 13C NMR and MS. Antitumor activities were evaluated in vitro using MTT assay on Leukemia cells (K562), human breast cancer cells (MB-231) and prostate cancer cells (Ln cap cell). The results showed that most of the six compounds were superior to the control (amonafide), 6d, 6e, and 6f exhibited nice selectivity in a screen of hepatoma cells (BEL-7402) and human normal hepatocytes (QSG-7701).
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